Teagasc studies conducted in 2018 and 2019 on Sexed Ultra 4M sexed semen on commercial farms found that conception rate was reduced when sexed semen was used. On average over the two years, the conception rate with sexed semen was 50%, while it was 61% with conventional semen. This 18% drop in relative conception rate represents a big cost at farm level. Using sexed semen across a herd would undo a lot of the fertility gains brought about by EBI over the last 20 years as it would lead to a more spread out calving pattern. However, in both studies, some herds had a conception rate comparable to or better than conventional semen. The reasons for this are not yet known but offer a glimmer of hope for sexed semen.